PANS is an acronym for Pediatric Acute-onset Neuropsychiatric Syndrome. PANDAS stands for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Strep. PANDAS is generally considered a subset of PANS.
Both disorders are the result of a misdirected immune response following an infection or illness. Children with PANDAS or PANS experience an acute onset of debilitating neuropsychiatric symptoms.
Sadness and Depression
Night-time Bed Wetting
Day-time Urinary Frequency
Fine/Gross Motor Changes (handwriting)
Deterioration in School Performance
Motor and/or Vocal Tics
Irritability and/or Aggression
Sensory or Motor Abnormalities
PANS is defined by the following criteria:
Abrupt, dramatic onset of OCD or severely restricted food intake; symptoms are not better explained by a known neurologic or medical disorder; and the addition of at least two of the “accompanying” symptoms:
- Emotional lability and/or depression
- Irritability, aggression and/or severely oppositional behaviors
- Behavioral (developmental) regression
- Deterioration in school performance
- Sensory or motor abnormalities
- somatic signs including sleep disturbances, enuresis or urinary frequency
The onset of PANS may start with infectious agents other than strep. It also includes onset from environmental triggers or immune dysfunction.
PANDAS is defined by the following criteria:
The clinical diagnosis of PANDAS includes 5 criteria:
- Presence of significant obsession, compulsions and/or tics
- Abrupt onset of symptoms or a relapsing-remitting course of symptom severity
- Prepubertal onset
- Association with streptococcal infection
- Association with other neuropsychiatrc symptoms (includes any of the PANS “accompanying” symptoms).
Other symptoms can include:
- Fixed ideas and thoughts/unwanted feelings
- Separation anxiety
- Mood changes (irritability, sadness, emotional liability)
- Sleep disturbance
- Night-time bed weting and/or day –time urinary frequency
- Fine/gross motor changes (e.g. changes in handwriting)
- Joint Pains.
- Motor and/or vocal tics
- General anxiety
- Oppostitional defiance